Fig. 1. (A) Circulating platelet numbers in rats intratracheally instilled with either saline (control) or cerium oxide nanoparticles (CNPs), with or without cisplatin (CDDP) administration. (B) Platelet aggregation in whole blood obtained from either untreated control rats with or without the addition of adenosine diphosphate (ADP; 0.1 μM) or rats intratracheally instilled with either saline or cerium oxide nanoparticles (CNPs), with or without cisplatin (CDDP) administration. Data are presented as means ± SEM (n=5-8).